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Eur Respir J 3: 27–32, Weinberger M (1984) Pharmacology and therapeutic use of theophylline. Xanthines act as mild stimulants and help to improve breathing. DRUGS FOR BRONCHIAL ASTHMA . of asthma and were subsequently maintained on a reg­ imen with the assigned medication for a further 11 months. However, because they have a relatively narrow margin of safety and interact with many other drugs, they are no longer considered the first-choice bronchodilators. The xanthine drugs are clinically effective in asthma. Clinical Application Case Study. Br Med J 297: 1506–1510, Clark H, Cushley MJ, Persson CGA, Holgate ST (1989) The protective effects of intravenous theophylline and enprofylline against histamine-and adenosine-5’- monophosphate-provoked bronchoconstriction: implications for the mechanisms of action of xanthine derivatives in asthma. Br J Pharmacol 93: 909–917, Lunell E, Svedmyr N, Andersson KE, Persson CGA (1983) A novel broncholdilator xanthine apparently without antagonism and tremorogenic effect. Bronchodilator actions of xanthine derivatives administered by inhalation in asthma. Asthma management, COPD management, and Apnea of prematurity. The main role of theophylline and dyphylline is to help maintain good airway control in chronic, persistent, airways disease. Biochem Pharmacol 29: 1085–1092, https://doi.org/10.1007/978-3-642-75855-3_7. The main drug in this category, prazosin, could be of theoretic value in asthma, since α-agonist stimulation in the lung can induce bronchospasm. Factors Affecting Theophylline ... Bronchiolitis, bronchiectasis, & asthma Use only if pt has thick secretions w/o a productive cough-causes bronchostiction. In: O’Donnell SR, Persson CGA (eds) Directions for new antiasthma drugs. In contrast to other, more potent stimulants like sympathomimetic amines, xanthines mainly act to oppose the actions of adenosine, and increase alertness in the central nervous system. Directions for New Antiasthma Drugs. However, in the customary hypotensive therapy dosages, prazosin does not appear to have significant effects on the bronchial muscle, What is caffeine citrate? This medication works best when taken on an empty stomach one hour before or two hours after meals. The methylxanthine theophylline has demonstrated efficacy in attenuating the three cardinal features of asthma - reversible airflow obstruction, airway hyperresponsiveness, and airway inflammation. Am Rev Respir Dis 135: 1069–1074, Harada H, Ishizaka A, Yonemaru M, Mallick AA, Hatherill JR, Zheng H, Lilly CM, O’Hanley PT (1989) The effects of aminophylline and pentoxifylline on multiple organ damage after escherichia coli sepsis. This book (in paperback format) has sample TMC Practice Questions … Download preview PDF. Drugs used to treat Asthma The following list of medications are in some way related to, or used in the treatment of this condition. They treat asthma, COPD, allergies, and other breathing problems. In: Mygind N, Pipkorn U, Dahl R (eds) Rhinitis and asthma. The derivatives of xanthine that are used most commonly in medicine have a methyl, or CH3, group on them. Not logged in Excerpts, Amsterdam, pp 223–229, Kröll F, Karlsson JA, Nilsson E, Ryrfeldt Å, Persson CGA (1990) Rapid clearance of xanthines from airway and pulmonary tissues. Birkhauser, Basel, pp 37–54, Vilsvik JS, Persson CGA, Amundsen T et al. Pharmacology has played a critical role in asthma drug development and several key experimental observations have been published in this journal. If stomach upset occurs, it may be taken with food. Not affiliated Eur J Clin Pharmacol 32: 389–393, Barnes PJ, Greening AP, Neville L, Timmers J, Poole GW (1982) Single-dose slow release aminophylline at night prevents nocturnal asthma. Xanthines, best represented by theophylline, constitute a pharmacological principle of considerable age and importance in the treatment of asthma. Bronchodilators are drugs that open the airways of the lungs. This medication belongs to a class of drugs known as xanthines. It works by relaxing the muscles around the airways so that they open up and you can breathe more easily. Church MK, Featherstone RL, Cushley MJ, Mann JS, Holgate ST. Methylxanthines have been used for the treatment of asthma for more than 60 years, but their mechanism of action is poorly understood. Understand how to use the nursing process in the care of patients with asthma and bronchoconstriction. every 2-4 weeks in allergic/eosinophilic asthma. Their ability to inhibit cyclic adenosine monophosphate phosphodiesterase has attracted much attention. 5. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Part of Springer Nature. Clin Allergy 18: 143–150, Cartier A, Lemaire I, L’Archeveque J, Ghezzo H, Martin RR, Malo JL (1986) Theophylline partially inhibits bronchoconstriction caused by inhaled histamine in subjects with asthma. Theophylline is the methyl xanthine, which has a major role in the management of asthma and EIB. There are multiple modes of action, and different drugs exert varying selectivities. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. METHYLXANTHINE DRUGS. Pregnancy and breastfeeding safety information are provided. 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